王蓮成（Lian-Chen Wang）

職稱：教授

研究室名稱：寄生蟲免疫研究室

最高學歷：Ph.D.

學校/國家：高雄醫學大學/台灣

分機號碼：5092

電子郵件帳號： wanglc@mail.cgu.edu.tw

個人網頁網址：

研究室現有： 博士後研究員 1  人

博士班研究生  1  人

碩士班研究生 1 人

專任研究助理  2  人

大學部專題生   1  人

研究方向及研究室特色：
A、廣東住血線蟲之研究
1. 廣東住血線蟲第三期及第五期幼蟲表現序列標幟之分析
2. 廣東住血線蟲分泌性蛋白的選殖與分析
3. 應用磁振造影於廣東住血線蟲症之探討
4. 不同宿主感染廣東住血線蟲後腦部之病理學研究
5. 廣東住血線蟲免疫診斷方法之研究
B、寄生蟲疾病之流行病學調查

最近五年所發表論文：

1. Chen, K.Y., Chen, Y.J., Cheng, C.J., Jhan, K.Y., Chiu, C.H. & Wang, L.C. 2020. 3-Hydroxybenzaldehyde and 4-Hydroxybenzaldehyde enhance survival of mouse astrocytes treated with Angiostrongylus cantonensis young adults excretory/secretory products. Biomedical Journal. 10.1016/j.bj.2020.11.008. (SCI)
2. Cheng, C.C., Yang, C.F., Lo, Y.P., Chiang, Y.H., Sifiyatun, E., Wang, L.C. & Chen, W.J.2020. Cell-to-cell spread of dengue viral RNA in mosquito cells. BioMed Research International 10.1155/2020/2452409. (SCI)
3. Jhan, K.Y., Lai, G.J., Chang, P.K., Tang, R.Y., Cheng, C.J., Chen, K.Y. & Wang, L.C. 2020. Angiostrongylus cantonensis causes cognitive impairments in heavily infected BALB/c and C57BL/6 mice. Parasites & Vectors 10;13(1):405. (SCI)
4. Chen, K.Y., Cheng, C.J., Cheng, C.C., Jhan K.Y., Chen, Y.J. & Wang, L.C. 2020. The excretory/secretory products of fifthstage larval Angiostrongylus cantonensis induces autophagy via the Sonic hedgehog pathway in mouse brain astrocytes. PLOS Neglected Tropical Diseases 14(6): e0008290. (SCI)
5. Chen, K.Y., Chen, Y.J., Cheng, C.J., Jhan, K.Y. & Wang, L.C. 2020. Excretory/secretory products of Angiostrongylus cantonensis fifth-stage larvae induce endoplasmic reticulum stress via the Sonic hedgehog pathway in mouse astrocytes. Parasites & Vectors 18;13(1):317. (SCI)
6. Chen, K.Y., Lu P.J., Cheng C.J., Jhan K.Y., Yeh J. S. & Wang, L.C. 2019. Proteomic analysis of excretory-secretory products from young adults of Angiostrongylus cantonensis. Memórias do Instituto Oswaldo Cruz 114:e180556. (SCI)
7. International Helminth Genomes Consortium. 2019. Comparative genomics of the major parasitic worms. Nature Genetics 51(1): 163–174. (SCI)
8. Wang, T. Y., Chen, K.Y., Jhan K.Y., Li, C. H., Jung, S. M. & Wang, L.C. 2018. Temporal-spatial expressions of interleukin-4, interleukin-10, and interleukin-13 in thebrains of C57BL/6 and BALB/c mice infected with Angiostrongylus cantonensis: An immunohistochemical study. Journal of microbiology, immunology, and infection 10.1016/j.jmii.2018.10.010.(SCI)
9. Chen, T.H., Wu, Y.J.; Hou, J.N., Chiang, Y.H., Cheng, C.C., Sifiyatun, E., Chiu, C.H., Wang, L.C. & Chen, W.J. 2018. A novel p53 paralogue mediates antioxidant defense of mosquito cells to survive dengue virus replication. Virology 519: 516-519(SCI)
10. Chen, K.Y., Yen, C.M., Hwang, K.P. & Wang, L.C. 2018. Enterobius vermicularis infection and its risk factors among pre-school children in Taipei, Taiwan. Journal of microbiology, immunology, and infection 51(4):559-564(SCI)
11. Lo, Y.L., Chen, C.L., Shen, L., Chen, Y.C., Wang, Y.H., Lee, C.C., Wang, L.C., Chuang, C.H., Janapatla, R.P., Chiu, C.H., Chang, H.Y. 2018. Characterization of the role of global regulator FliA in the pathophysiology of Pseudomonas aeruginosa infection. Research in Microbiology 169(3): 135-144(SCI)
12. Chen, K.Y. & Wang, L.C. 2017. Stimulation of IL-1β and IL-6 through NF-κB and sonic hedgehog-dependent pathways in mouse astrocytes by excretory/secretory products of fifth-stage larval Angiostrongylus cantonensis. Parasites & vectors 10(1):445(SCI)
13. Chen, K.Y., Chiu, C.H. & Wang, L.C. 2017. Anti-apoptotic effects of Sonic hedgehog signalling through oxidative stress reduction in astrocytes co-cultured with excretory-secretory products of larval Angiostrongylus cantonensis. Scientific Reports 7:41574(SCI)