跳到主要內容區
  1. 首頁
  2. 微生物暨免疫學組

邱政洵

邱政洵 (Cheng-Hsun Chiu)

職稱：教授

研究室名稱：分子感染症醫學研究中心

最高學歷：Ph.D.

學校/國家：

分機號碼：403-7943

電子郵件帳號： chchiu@cgmh.org,tw

個人網頁網址：https://www1.cgmh.org.tw/intr/intr2/c3s000/research/infection_11.html

研究室現有： 博士後研究員 1  人

博士班研究生  0  人

碩士班研究生0  人

專任研究助理  13  人

大學部專題生  0   人

研究方向及研究室特色：

研究室特色

學組名稱

研究方向
  1. 提供合適、均衡、技術性和知識性的研究環境。
  2. 帶動研究風氣的形成與發展。
  3. 指導各類研究計劃之設計與申請。
  4. 協助研究成果發表於優秀論文期刊。

臨床研究組

本土重要病毒與細菌感染之流行病學及感染症治療及預防之臨床試驗

轉譯醫學組

重要新興感染症相關:

a.診斷試劑、方法之開發

b.新治療方法研究

c.疫苗研發

微生物致病機制組

重要致病原:

a.沙門氏菌

b.口腔鏈球菌

c.A型鏈球菌

d.肺炎鏈球菌

e.金黃色葡萄球菌

f.腸道Microbiota及困難梭狀桿菌

除了致病機制（pathogenesis）還包括

Host-pathogen interaction

微生物基因體學組
  1. 肺炎鏈球菌、鮑氏不動桿菌、B型鏈球菌及沙

門氏菌之population genomics

b.以NGS捕捉細菌基因體突變之軌跡及趨向

c. Gut 16S microbiota 及metagenomics

最近五年所發表論文：

  1. Wu CT, Lee HY, Chen CL, Tuan PL, Chiu CH*. High prevalence and antimicrobial resistance of urinary tract infection isolates in febrile young children without localizing signs in Taiwan. J Microbiol Immunol Infect 2016;49:243-8.
  2. Wu TS, Yang CH, Brown-Elliott BA, Chao AS, Leu HS, Wu TL, Lin CS, Griffith DE, Chiu CH*. Postcesarean section wound infection caused by Mycobacterium massiliense. J Microbiol Immunol Infect 2016;49:955-61.
  3. Yang WC, Chan OW, Wu TL, Chen CL, Su LH, Chiu CH*. Development of ceftriaxone resistance in Salmonella enterica serotype Oranienburg during therapy for bacteremia. J Microbiol Immunol Infect 2016;49:41-5.
  4. Janapatla RP, Hsu MH, Liao WT, Chien KY, Lee HY, Chiu CH*. Low serum fetuin-A as a biomarker to predict pneumococcal necrotizing pneumonia and hemolytic uremic syndrome in children. Medicine (Baltimore) 2016;95:e3221.
  5. Feng Y, Ruan Z, Shu J, Chen CL, Chiu CH*. A glimpse into evolution and dissemination of multidrug-resistant Acinetobacter baumannii isolates in East Asia: a comparative genomics study. Sci Rep 2016;6:24342.
  6. Lin JJ, Chan OW, Hsiao HJ, Wang Y, Hsia SH, Chiu CH*. Decreased ADAMTS 13 activity is associated with disease severity and outcome in pediatric severe sepsis. Medicine (Baltimore) 2016;95:e3374.
  7. Wang PL, Chen SY, Tsai CN, Chao HC, Lai MW, Chang YJ, Chen CL, Chiu CH*. Complicated norovirus infection and assessment of severity by a modified Vesikari disease score system in hospitalized children. BMC Pediatr 2016;16:162.
  8. Huang KY, Wang YH, Chien KY, Janapatla RP, Chiu CH*. Hyperinvasiveness of Salmonella enterica serovar Choleraesuis linked to hyperexpression of type III secretion systems in vitro. Sci Rep 2016;6:37642.
  9. He EM, Chen CW, Guo Y, Hsu MH, Zhang L, Chen HL, Zhao GP, Chiu CH*, Zhou Y. The genome of serotype VI Streptococcus agalactiae serotype VI and comparative analysis. Gene 2017;597:59-65.
  10. Chuang CH, Janapatla RP, Wang YH, Chang HJ, Huang YC, Lin TY, Chiu CH*. Pseudomonas aeruginosa-associated diarrheal diseases in children. Pediatr Infect Dis J 2017; 36:1119-23.  
  11. Chia JH, Feng Y, Su LH, Wu TL, Chen CL, Liang YH, Chiu CH*. Clostridium innocuum is a significant vancomycin-resistant pathogen for extraintestinal clostridial infection. Clin Microbiol Infect 2017;23:560-6.
  12. Chen SY, Tsai CN, Lee YS, Lin CY, Huang KY, Chao HC, Lai MW, Chiu CH*. Intestinal microbiome in children with severe and complicated acute viral gastroenteritis. Sci Rep 2017;7:46130.
  13. Chen HH, Li HC, Su LH, Chiu CH*. Fluoroquinolone-nonsusceptible Streptococcus pneumoniae isolates from a medical center in the pneumococcal conjugate vaccine era. J Microbiol Immunol Infect 2017; 50:839-45.
  14. Janapatla RP, Su LH, Chen HH, Chang HJ, Tsai TC, Chen PY, Chen CL, Chiu CH*. Epidemiology of culture-confirmed infections of Streptococcus pneumoniae (2012-2015) and nasopharyngeal carriage in children and households in Taiwan (2014-2015). J Med Microbiol 2017;66:729-36.
  15. Feng Y, Chen HL, Chen CJ, Chen CL, Chiu CH*. Genome comparison of two Taiwanese community-associated methicillin-resistant Staphylococcus aureus ST59 clones support the multi-origin therapy of CA-MRSA. Infect Genet Evol 2017;54:60-5.
  16. Lin HJ, Liu HH, Lin CD, Kao MC, Chen YA, Chiang-Ni C, Jiang ZP, Huang MZ, Lin CJ, Lo UG, Lin LC, Lai CK, Lin H, Hsieh JT, Chiu CH*, Lai CH. Cytolethal distending toxin enhances radiosensitivity in prostate cancer cells by regulating autophagy. Front Cell Infect Microbiol. 2017;7:223.
  17. Lin JJ, Hsiao HJ, Chan OW, Wang Y, Hsia SH, Chiu CH*. Increased serum thrombomodulin level is associated with disease severity and mortality in pediatric sepsis. PLoS One 2017;12:e0182324.
  18. Lee HY, Hsu SY, Hsu JF, Chen CL, Wang YH, Chiu CH*. Risk factors and molecular epidemiology of Acinetobacter baumannii bacteremia in neonates. J Microbiol Immunol Infect 2018;51:367-76.
  19. Lee HY, Chiu CH*. Efficacy and safety of using colistin in neonates. Pediatr Neonatol 2017;58:473-4.
  20. Lee HY, Wu TL, Su LH, Li HC, Janapatla RP, Chen CL, Chiu CH*. Invasive pneumococcal disease caused by ceftriaxone-resistant Streptococcus pneumoniae in Taiwan. J Microbiol Immunol Infect 2018;51:500-9.
  21. Wu PW, Huang CC, Chao WC, Sun CC, Chiu CH*, Lee TJ. Impact of influenza vaccine on childhood otitis media in Taiwan: a population-based study. PLoS One 2018; 13:e0190507.
  22. Lee HY, Chen CL, Chiu CH*. An atlantoaxial rotator subluxation secondary to a parapharyngeal abscess. Pediatr Neonatol 2018;59:423-4.
  23. Lo YL, Chen CL, Shen L, Chen YC, Wang YH, Lee CC, Wang LC, Chuang CH. Janapatla RP, Chiu CH*, Chang HY. Characterization of the role of global regulator FliA in the pathogenicity of Pseudomonas aeruginosa infection. Res Microbiol 2018; 169:135-44.
  24. Chia JH, Wu TS, Wu TL, Chen CL, Chuang CH, Su LH, Chang HJ, Lu CC, Kuo AJ, Lai CH, Chiu CH*. Clostridium innocuum is a vancomycin-resistant pathogen that may cause antibiotic-associated diarrhea. Clin Microbiol Infect 2018;24:1195-9.
  25. Janapatla RP, Chen CL, Hsu MH, Liao WT, Chiu CH*. Immunization with pneumococcal neuraminidases NanA, NanB and NanC to generate neutralizing antibodies and to increase survival in mice. J Med Microbiol 2018;67:709-23.
  26. Son S, Thamlikitkul V, Chokephaibulkit K, Perera J, Jayatilleke K, Hsueh PR, Lu CY, Balaji V, Moriuchi H, Nakashima Y, Lu M, Yang Y, Yao K, Kim SH, Song JH, Kim S, Kim MJ, Heininger U, Chiu CH*, Kim YJ. Prospective multinational serosurveillance study of Bordetella pertussis infection among 10- to 18-year-old Asian children and adolescents. Clin Microbiol Infect 2019; 25:250.e1-250.e7.
  27. Hsu JF, Chen CL, Lee CC, Lien R, Chu SM, Fu RH, Chiang MC, Yang CY, Lai MY, Wu IH, Yen TS, Chiu CH*. Characterization of group B Streptococcus colonization in full-term and Late-Preterm neonates in Taiwan. Pediatr Neonatol 2019; 60:311-7.
  28. Huang CC, Wu PW, Chen CL, Wang CH, Lee TJ, Ysai CN, Chiu CH*. IL-17A expression in the adenoid tissue from children with sleep disordered breathing and its association with pneumococcal carriage. Sci Rep 2018;8:16770.
  29. Lo CW, Liu HC, Lee CC, Lin CL, Chen CL, Jeng MJ, Chiu CH*. Serotype distribution and clinical correlation of Streptococcus agalactiae causing invasive disease in infants and children in Taiwan. J Microbiol Immun Infect 2019;52:578-84.
  30. Lee CC, Hsu JF, Prasad Janapatla R, Chen CL, Zhou YL, Lien R, Chiu CH*. Clinical and microbiological characteristics of group B Streptococcus from pregnant women and diseased infants in intrapartum antibiotic prophylaxis era in Taiwan. Sci Rep 2019;9:13525.
  31. Chen CH, Su LH, Li HC, Hsu MH, Wu TL, Chen CL, Kuo KC, Hsiao CC, Chiu CH*. Evaluation of the impact of 13-valent pneumococcal conjugate vaccine immunization in children by surveillance of culture-confirmed pneumococcal disease: A prospective clinical microbiological study. Vaccine 2019;37:5147-52.
  32. Lee HY, Hsiao HL, Chia CY, Cheng CW, Tsai TC, Deng ST, Chen CL, Chiu CH*. Risk factors and outcomes of Clostridium difficile infection in hospitalized patients. Biomed J. 2019;42:99-106.
  33. Feng Y, Lin E, Zou S, Chen CL, Chiu CH*. Complete genome sequence of Salmonella enterica serovar Sendai shows H antigen convergence with S. Miami and recent divergence from S. Paratyphi A. BMC Genomics 2019;20:398.
  34. Tsai MH, Liang YH, Chen CL, Chiu CH*. Characterization of Salmonella resistance to bile during biofilm formation. J Microbiol Immunol Infect 2020;53:518-24.
  35. Chen CL, Su LH, Janapatla RP, Lin CY, Chiu CH*. Genetic analysis of virulence and antimicrobial-resistant plasmid pOU7519 in Salmonella enterica serovar Choleraesuis. J Microbiol Immunol Infect 2020;53:49-59.
  36. Feng Y, Chang YJ, Fang SH, Su LH, Li HC, Yang HP, Yu MJ, Chiu CH*. Emergence and evolution of high-level cephalosporin-resistant Salmonella Goldcoast in northern Taiwan. Open Forum Infect Dis 2019;6(12):ofz447.
  37. Lin HH, Chen HL, Weng CC, Janapatla RP, Chen CL, Chiu CH*. Activation of apoptosis by Salmonella pathogenicity island-1 effectors through both intrinsic and extrinsic pathways in Salmonella-infected macrophages. J Microbiol Immunol Infect 2020;S1684-1182(20)30036-0. [published online ahead of print, 2020 Feb 26].
  38. Cao Q, Chen YC, Chen CL, Chiu CH*. SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics. J Formos Med Assoc 2020;119:670-3.
  39. Chen YC, Chen HH, Janapatla RP, Dudek A, Hsu MH, Chen CL, Chiu CH*. Thomsen-Friedenreich antigen activation as a predictor for clinical outcome of pediatric patients with invasive pneumococcal disease. Pediatr Neonatol 2020;61:338-42.
  40. Chiu CH, Lee JJ, Wang MH, Chu C. Genetic analysis and plasmid-mediated blaCMY-2 in Salmonella and Shigella and the ceftriaxone susceptibility regulated by the ISEcp-1-tnpA-blaCMY-2-blc-sugE. J Microbiol Immunol Infect 2020 Feb 28;S1684-1182(20) 30009-8.
  41. Chiang MC, Chen CL, Feng Y, Chen CC, Lien R, Chiu CH*. Lactobacillus rhamnosus sepsis associated with probiotic therapy in an extremely preterm infant: Pathogenesis and a review for clinicians. J Microbiol Immunol Infect 2020;S1684-1182(20)30089-X. doi:10.1016/j.jmii.2020.03.029  [published online ahead of print, 2020 Apr 3].
  42. Chang YJ, Chen MC, Feng Y, Su LH, Li HC, Yang HP, Yu MJ, Chen CL, Chiu CH*. Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan. Pediatr Neonatol 2020;61:432-8.
  43. Chiu CH, Chiu CT. Drug-resistant bacteremia after fecal microbiota transplant. N Engl J Med 2020;382:1960-1.
  44. Janapatla RP, Hsu MH, Chen CL, Wei SH, Yu MJ, Su LH, Lin TY, Chiu CH*. Persistence of immunity in children immunised with 13-valent pneumococcal conjugate vaccine and impact on nasopharyngeal carriage: a cross-sectional study. Thorax 2020;75:689-92.
  45. Chen CH, Chen CL, Arguedas A, Southern J, Hsiao CC, Chiu CH*. Divergent serotype distribution between children with otitis media and those without in the pneumococcal conjugate vaccine era. J Microbiol Immunol Infect 2020;53:1035-8.
  46. Chen HH, Hsu MH, Wu TL, Li HC, Janapatla RP, Su LH, Chiu CH*. Non-typeable Streptococcus pneumoniae infection in a medical center in Taiwan after wide use of pneumococcal conjugate vaccine. J Microbiol Immunol Infect 2020;53:94-8.
  47. Chiu CH, Tsai MC, Cheng HT, Le PH, Kuo CJ, Chiu CT. Fecal microbiota transplantation and donor screening for Clostridioides difficile infection during COVID-19 pandemic. J Formos Med Assoc 2021;120:791-3.
  48. Feng Y, Chang YJ, Pan SC, Su LH, Li HC, Yang HP, Yu MJ, Chiu CH*. Characterization and source investigation of multidrug-resistant Salmonella Anatum from a sustained outbreak, Taiwan. Emerg Infect Dis 2020;26:2951-5.
  49. Chiu TW, Peng CJ, Chen MC, Hsu MH, Liang YH, Chiu CH*, Fang JM, Lee YC. Constructing conjugate vaccine against Salmonella Typhimurium using lipid-A free lipopolysaccharide. J Biomed Sci 2020;27:89.
  50. Lin E, Zou S, Wang Y, Lee CC, Chiu CH*, Feng Y. Phylogeny, recombination, and invasiveness of group B Streptococcus revealed by genomic comparisons of its global strains. Eur J Clin Microbiol Infect Dis 2020 Oct 16:1–10. doi: 10.1007/s10096-020-04067-4. Epub ahead of print. PMID: 33067737; PMCID: PMC7567417.
  51. Chen YC, Chiu CH*. Additional concerns regarding children with coronavirus disease 2019. JAMA Pediatr. 2020;174:1216-17.
  52. Chen JC, Ou LS, Kuo ML, Tseng LY, Chang HL, Chen SC, Chiu CH*. Fetal macrophages exposed to Salmonella antigens elicit protective immunity against overwhelming Salmonella challenge in a murine model. Biomedicines 2021 Mar 1;9(3):245. doi: 10.3390/biomedicines9030245. PMID: 33804435; PMCID: PMC8001423.
  53. Wu CY, Chen YC, Lee WI, Huang JL, Chen LC, Ou LS, Yao TC, Jaing TH, Chen SH, Liang CJ, Kang CC, Chiu CH*. Clinical features of female Taiwanese carriers with X-linked chronic granulomatous disease from 2004 to 2019. J Clin Immunol 2021 May 8. doi: 10.1007/s10875-021-01055-x. Epub ahead of print. PMID: 33963972.
  54. Chen YC, Yang HP, Li HC, Huang PY, Chen CL, Chiu CH*. Features and transmission dynamics of SARS-CoV-2 superspreading events in Taiwan: Implications for effective and sustainable community-centered control. Pediatr Neonatol 2021 May 29:S1875-9572(21)00093-0. doi: 10.1016/j.pedneo.2021.05.012. Epub ahead of print. PMID: 34120866; PMCID: PMC8164498.
瀏覽數:
友善列印