蘇文慧 (Wen-Hui Su)

職稱：副教授

研究室名稱：癌症系統生物學研究室

最高學歷：Ph.D.

學校/國家：國防醫學院/台灣

分機號碼：+886-3-211-8800 ext. 3564

電子郵件帳號： whsu@mail.cgu.edu.tw

個人網頁網址：

研究室現有： 博士後研究員 0 人

博士班研究生 1人

碩士班研究生 2人

專任研究助理  1 人

大學部專題生  1 人

研究方向及研究室特色：

    癌症做為一種遺傳的疾病，許多關於癌症的變化，常是先在染色體中發生，進而影響基因的表現，而導致癌症發生，或形成癌症特殊的標誌。我們在染色體上找到與癌症相關的變化，可以分為兩大類。一類為在生殖細胞(germline cells)就有的變異，例如單一核酸變異(SNP)或是複製數變異(copy number variation)，讓帶有這些變異或基因型的人較其他人更容易得病，我們可以利用全基因體關聯性分析(genome-wide association study) 的方法，來研究有哪些變異會造成對疾病的感受性的差異。進而去找到造成這種感受性差異的癌症基因。另一類，則是在體細胞(somatic cells)中成形的癌組織內，常會見到的是染色體畸變(chromosome aberration)和基因表現改變的現象，我們也可以利用生物資訊和比較基因體學的方法，將目前已有的這些資訊整合起來，試著找出與癌症的標誌基因。在我們實驗室裏，就是試著以系統生物學和遺傳統計的方法，將這些訊息進行整合，試著找出與鼻咽癌(nasopharyngeal carcinoma)和肝癌(hepatocellular carcinoma)相關的感受性標誌及標誌基因。

最近五年所發表論文：

1.  Wang Jin, Zhao Lei, Sun Xu, Zhou Fachen, Zhang Yixiang, Zhao Shilei, Guo Tao, Sun Zhe, Li Fengzhou, Wen-Hui Su, and Gu Chundong (2021) Genetic Mutation Analysis in Small Cell Lung Cancer by a Novel NGS-Based Targeted Resequencing Gene Panel and Relation with Clinical Features. BioMed Research International 2021 Article ID 3609028 (SCI: Impact factor: 2.276, 92/156 BIOTECHNOLOGY & APPLIED MICROBIOLOGY).

2.  Muyun Peng, Qi Huang, Wei Yin, Sichuang Tan, Chen Chen, Wenliang Liu, Jingqun Tang, Xiang Wang, Bingyu Zhang, Min Zou, Jina Li, Wenhui Su, Lientu Wang, Lihan Chin and Fenglei Yu (2020) Circulating Tumor DNA as a Prognostic Biomarker in Localized Non-small Cell Lung Cancer. Frontiers in Oncology 10: 1875 (SCI: Impact factor: 4.848, 69/244 ONCOLOGY)

3.  Xiao-Yu Zuo, Qi-Sheng Feng, Jian Sun, Pan-Pan Wei, Yoon-Ming Chin, Yun-Miao Guo, Yun-Fei Xia, Bo Li, Xiao-Jun Xia, Wei-Hua Jia, Jian-Jun Liu, Alan Soo-Beng Khoo, Taisei Mushiroda, Ching-Ching Ng*, Wen-Hui Su*, Yi-Xin Zeng*, and Jin-Xin Bei* (2019) X-chromosome association study reveals genetic susceptibility loci of nasopharyngeal carcinoma. Biology of Sex Differences 10:13 (SCI: Impact factor: 3.267, 72/177 GENETICS & HEREDITY) (*equal contributed corresponding author)

4.  Wen-Hui Su*, Yuh-Shan Jou, Jia-Hao Zhang, Chun-Ming Ho, Dar-In Tai (2018) Mutations in NOTCH1 and nucleotide excision repair genes are correlated with prognosis of hepatitis B virus-associated hepatocellular carcinoma. Journal of Cancer 9(15): 2678-2686 (SCI: Impact factor: 3.565, 105/244 ONCOLOGY) (*Corresponding author) (NSC 100-2320-B-182-005, MOST 104-2314-B-182-033-MY3, BMRPC18, CMRPD3D0121, CMRPD3D0122, CMRPD3D0123)

5.  The Telomeres Mendelian Randomization Collaboration (2017) Association between telomere length and risk of cancer and non-neoplastic diseases a mendelian randomization study. JAMA Oncology 3(5):636-651 (SCI: Impact factor: 24.799, 8/244 ONCOLOGY)

6.  Jin-Xin Bei†, Wen-Hui Su†, Ching-Ching Ng†, Kai Yu, Yoon-Ming Chin, Pei-Jen Lou, Wan-Lun Hsu, James D. McKay, Chien-Jen Chen, Yu-Sun Chang, Jian-Jun Liu, Yi-Xin Zeng, and Allan Hildesheim for the International Nasopharyngeal Carcinoma Genetics Working Group (2016) A GWAS meta-analysis and replication study identifies a novel locus within CLPTM1L/TERT associated with nasopharyngeal carcinoma in individuals of Chinese ancestry. Cancer Epidemiology Biomarkers & Prevention 25(1):188-92 (SCI: Impact factor: 4.344, 25/193 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH) (†equal contributed first author)